6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-B]-噻唑
SKF-86002(6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PYRIDINYL)IMIDAZO[2,1-B]THIAZOLE DIHYDROCHLORIDE)
CAS: 72873-74-6
化学式: C16H12FN3S
| 中文名 | SKF-86002 |
| 英文名 | 6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PYRIDINYL)IMIDAZO[2,1-B]THIAZOLE DIHYDROCHLORIDE |
| 别名 | 6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-B]-噻唑 |
| 英文别名 | SKF-86002 SKF 86002 DIHYDROCHLORIDE 6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PYRIDYL)IMIDAZO[2,1-B]THIAZOLE 6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PRIDYL)IMIDAZO-[2,1,B]-THAIZOLE 6-(4-FLUOROPHENYL)-5-(4-PYRIDYL)-2,3-DIHYDROIMIDAZO[2,1-B]-THIAZOLE 6-(4-fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo(2,1-b)thiazole 4-(4-Pyridyl)-5-(4-fluorophenyl)-2,3-dihydro-1-thia-3a,6-diazapentalene 6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PYRIDINYL)IMIDAZO[2,1-B]THIAZOLE DIHYDROCHLORIDE |
| CAS | 72873-74-6 |
| 化学式 | C16H12FN3S |
| 分子量 | 297.35 |
| InChIKey | YOELZIQOLWZLQC-UHFFFAOYSA-N |
| 密度 | 1.39±0.1 g/cm3(Predicted) |
| 熔点 | 189-190°C(lit.) |
| 沸点 | 476.1±55.0 °C(Predicted) |
| 溶解度 | DMSO: 9mg/ml，可溶 |
| 酸度系数 | 4.36±0.10(Predicted) |
| 存储条件 | Keep in dark place,Sealed in dry,2-8°C |
| 外观 | 固体 |
| 颜色 | off-white |
| 体外研究 | SKF-86002 (10 μM; 1 hour) inhibits apoptosis induced by stress stimulation with UV irradiation (UV). SKF-86002 does not inhibit UV-induced apoptosis in undifferentiated HL-60 cells. SKF-86002 (10 μM; 72 hours) prevent IL-4-induced monocyte or U937 cell CD23 surface expression and protein formation with no effect on CD23 mRNA levels. Western Blot Analysis Cell Line: U937 cells Concentration: 10 μM Incubation Time: 72 hours Result: Significantly reduced CD23 levels on IL-4-treated U937 cells. |
| 体内研究 | SKF-86002 (10-90 mg/kg; p.o.; daily; for 22 days) has antiarthritic activity. Animal Model: Lewis rats, with adjuvant-induced arthritis (AA) Dosage: 10 mg/kg, 30 mg/kg, 90 mg/kg Administration: Oral administration, daily, for 22 days Result: Significantly decreased hindleg volumes after injection of adjuvant. |
| 危险品标志 | Xi - 刺激性物品 |
| 风险术语 | 36/37/38 - 刺激眼睛、呼吸系统和皮肤。 |
| 安全术语 | S26 - 不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。 S36 - 穿戴适当的防护服。 |
| WGK Germany | 3 |
6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-B]-噻唑 - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.363 ml | 16.815 ml | 33.629 ml |
| 5 mM | 0.673 ml | 3.363 ml | 6.726 ml |
| 10 mM | 0.336 ml | 1.681 ml | 3.363 ml |
| 5 mM | 0.067 ml | 0.336 ml | 0.673 ml |
最后更新：2024-01-02 23:10:35
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产品名: 6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-b]-噻唑 去供应商网站查看 询盘CAS: 72873-74-6
产地: 中国上海
包装: 2mg
规格: 98%
价格: 139.00
库存: 现货
电话: 400-900-4166
手机: 18017137653
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微信: 18017137653
产品描述: 中文名：6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-b]-噻唑 英文名:SKF-86002 CAS:72873-74-6 规格:98% 更多
现货供应
产品名: 6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-b]-噻唑 去供应商网站查看 询盘CAS: 72873-74-6
产地: 中国上海
包装: 2mg
规格: 98%
价格: 139.00
库存: 现货
电话: 400-900-4166
手机: 18017137653
电子邮件: 3007523013@qq.com
QQ: 3007523013
微信: 18017137653
产品描述: 中文名：6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-b]-噻唑 英文名:SKF-86002 CAS:72873-74-6 规格:98% 更多
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